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Article

Structural model of the M7G46 Methyltransferase TrmB in complex with tRNA.

RNA biology - 1 Dec 2021

Blersch Katharina F, Burchert Jan-Philipp, August Sophie-Charlotte, Welp Luisa, Neumann Piotr, Köster Sarah, Urlaub Henning, Ficner Ralf

Abstract excerpt

TrmB belongs to the class I S-adenosylmethionine (SAM)-dependent methyltransferases (MTases) and introduces a methyl group to guanine at position 7 (m7G) in tRNA. In tRNAs m7G is most frequently found at position 46 in the variable loop and forms a tertiary base pair with C13 and U22, introducing a positive charge at G46. The TrmB/Trm8 enzyme family is structurally diverse, as TrmB proteins exist in a monomeric,...

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Identifiers

PMID: 34006170
DOI: 10.1080/15476286.2021.1925477
PMCID: PMC8632124

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