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Article

Specific chromosome alterations in fluconazole-resistant mutants of Candida albicans.

Journal of bacteriology - 1 Jul 1999

Perepnikhatka V, Fischer F J, Niimi M, Baker R A, Cannon R D, Wang Y K, Sherman F, Rustchenko E

Abstract excerpt

The exposure of Candida albicans to fluconazole resulted in the nondisjunction of two specific chromosomes in 17 drug-resistant mutants, each obtained by an independent mutational event. The chromosomal changes occurred at high frequencies and were related to the duration of the drug exposure. The loss of one homologue of chromosome 4 occurred after incubation on a fluconazole medium for 7 days. A second change,...

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Source

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Identifiers

PMID: 10383973
DOI: 10.1128/JB.181.13.4041-4049.1999
PMCID: PMC93895

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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