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Article

5-fluoro-orotic acid induces chromosome alterations in genetically manipulated strains of Candida albicans.

Mycologia - 1 Jan 2000

Wellington Melanie, Kabir M Anaul, Rustchenko Elena

Abstract excerpt

We previously reported the occurrence of chromosome alterations in a Candida albicans prototrophic strain 3153A treated with 5-fluoro-orotic acid (5-FOA). In this study we investigated the mutagenic properties of 5-FOA with two derivatives of C. albicans strain CAF4-2 (ura3/ura3), each containing an ectopic copy of URA3 gene (ura3/ ura3 URA3) on a different chromosome. As expected, after the ura3/ura3 URA3...

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Identifiers

PMID: 17040068
DOI: 10.3852/mycologia.98.3.393

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