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Article

TGF-β1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells

21 Jun 2018

Abstract excerpt

Transforming growth factor β1 (TGF-β1) plays a role in the maintenance of quiescent hematopoietic stem cells (HSCs) in vivo. We asked whether TGF-β1 controls the cell cycle status of HSCs in vitro to enhance the reconstitution activity. To examine the effect of TGF-β1 on the HSC function, we used an in vitro culture system in which single HSCs divide with the retention of their short- and long-term reconstitution...

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PMID: 29937145
DOI: 10.1016/j.stemcr.2018.05.017

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