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Article

Influence of SHBG gene pentanucleotide TAAAA repeat and D327N polymorphism on serum sex hormone-binding globulin concentration in hirsute women.

The Journal of clinical endocrinology and metabolism - 1 Feb 2004

Cousin Patrice, Calemard-Michel Laurence, Lejeune Hervé, Raverot Gérald, Yessaad Nadia, Emptoz-Bonneton Agnès, Morel Yves, Pugeat Michel

Abstract excerpt

SHBG is the specific plasma transport protein for sex steroid hormones in humans. Plasma SHBG concentration follows a gender dimorphism but varies with nutritional and hormonal status in both sexes. In addition, a genetic influence on SHBG in humans has recently been suggested by family studies. We investigated the relationship between a point mutation (D327N) in SHBG gene exon 8 that delays human SHBG half-life...

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Identifiers

PMID: 14764814
DOI: 10.1210/jc.2002-021553

Genes

SHBG

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Influence of SHBG gene pentanucleotide TAAAA repeat and D327N polymorphism on serum sex hormone-binding globulin concentration in hirsute women.PMID 14764814Read ↗

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Association of the (TAAAA)n repeat polymorphism in the sex hormone-binding globulin (SHBG) gene with polycystic ovary syndrome and relation to SHBG serum levels.Semantic proximity Read ↗

The (TAAAA)n microsatellite polymorphism in the SHBG gene influences serum SHBG levels in women with polycystic ovary syndrome.Semantic proximity Read ↗

Association between the (TAAAA)n SHBG polymorphism and PCOS: a systematic review and meta-analysis.Semantic proximity Read ↗

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Role of D327N sex hormone-binding globulin gene polymorphism in the pathogenesis of polycystic ovary syndrome.Semantic proximity Read ↗

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Common genetic variation in the sex steroid hormone-binding globulin (SHBG) gene and circulating shbg levels among postmenopausal women: the Multiethnic Cohort.Semantic proximity Read ↗

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