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The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development

2 Jun 2017

Abstract excerpt

The zebrafish kidney is conserved with other vertebrates, making it an excellent genetic model to study renal development. The kidney collects metabolic waste using a blood filter with specialized epithelial cells known as podocytes. Podocyte formation is poorly understood but relevant to many kidney diseases, as podocyte injury leads to progressive scarring and organ failure. zeppelin ( zep ) was isolated in a...

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PMID: 28579318
DOI: 10.1016/j.ydbio.2017.05.025

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