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Article

Protein expression profiling of the drosophila fragile X mutant brain reveals up-regulation of monoamine synthesis.

Molecular & cellular proteomics : MCP - 1 Mar 2005

Zhang Yong Q, Friedman David B, Wang Zhe, Woodruff Elvin, Pan Luyuan, O'donnell Janis, Broadie Kendal

Abstract excerpt

Fragile X syndrome is the most common form of inherited mental retardation, associated with both cognitive and behavioral anomalies. The disease is caused by silencing of the fragile X mental retardation 1 (fmr1) gene, which encodes the mRNA-binding, translational regulator FMRP. Previously we established a disease model through mutation of Drosophila fmr1 (dfmr1) and showed that loss of dFMRP causes defects in...

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PMID: 15634690
DOI: 10.1074/mcp.M400174-MCP200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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