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Article

Genetic mutual relationship between PTEN and p53 in gastric cancer.

Cancer letters - 8 Sept 2005

Oki Eiji, Tokunaga Eriko, Nakamura Toshihiko, Ueda Naoyuki, Futatsugi Motonori, Mashino Kohjiro, Yamamoto Manabu, Watanabe Masayuki, Ikebe Masahiko, Kakeji Yoshihiro, Baba Hideo, Maehara Yoshihiko

Abstract excerpt

Both PTEN (encoding phosphate and tensin homologue) and p53 are known as cancer suppressor genes, and they are assumed that their gene mutations and loss of heterozygosity (LOH) occur frequently in various types of carcinoma. In the present study, we investigated both the p53 mutation and LOH of PTEN in 113 gastric cancer patients. We observed the LOH of PTEN in 11.1% of the patients with normal p53s and 46.2% of...

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Source

Identifiers

PMID: 16051030
DOI: 10.1016/j.canlet.2004.12.006

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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