Article
No association was found between a functional SNP in ZDHHC8 and schizophrenia in a Japanese case-control population.
Neuroscience letters - 1 Feb 2005
Saito Shinichi, Ikeda Masashi, Iwata Nakao, Suzuki Tatsuyo, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Takahashi Nagahide, Inada Toshiya, Ozaki Norio
Abstract excerpt
ZDHHC8 is a new and attractive candidate for a schizophrenia-susceptibility factor. First, several lines of linkage studies showed that 22q11, on which ZDHHC8 is located, is a "hot" region. Second, fine linkage disequilibrium mapping revealed a significant association around ZDHHC8. Moreover, a very recent study reported that one single nucleotide polymorphism (SNP: rs175174) in ZDHHC8 might affect the splicing...
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