Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8.

doi:10.1093/hmg/ddh322

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Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8.

Human molecular genetics - 1 Dec 2004

Chen Wu-Yan, Shi Yong-Yong, Zheng Yong-Lan, Zhao Xin-Zhi, Zhang Guang-Ji, Chen Sheng-Qi, Yang Pei-Di, He Lin

Abstract excerpt

Genetic variants in the 22q11 gene ZDHHC8, which encodes a putative transmembrane palmitoyltransferase, has been associated to schizophrenia in family-based linkage disequilibrium (LD) studies. The single nucleotide polymorphism (SNP) rs175174 (A/G), which had the strongest association, has been shown recently to regulate the level of the fully functional transcript by modulating the retention of intron 4 of...

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PMID: 15489219
DOI: 10.1093/hmg/ddh322

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ZDHHC8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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