Article
ZDHHC8 as a candidate gene for schizophrenia: analysis of a putative functional intronic marker in case-control and family-based association studies.
BMC psychiatry - 14 Oct 2005
Faul Thomas, Gawlik Micha, Bauer Martin, Jung Sven, Pfuhlmann Bruno, Jabs Burkhard, Knapp Michael, Stöber Gerald
Abstract excerpt
BACKGROUND: The chromosome 22q11 region is proposed as a major candidate locus for susceptibility genes to schizophrenia. Recently, the gene ZDHHC8 encoding a putative palmitoyltransferase at 22q11 was proposed to increase liability to schizophrenia based on both animal models and human association studies by significant over-transmission of allele rs175174A in female, but not male subjects with schizophrenia....
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