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Article

Fine-mapping of ZDHHC2 identifies risk variants for schizophrenia in the Han Chinese population.

Molecular genetics & genomic medicine - 1 Jul 2020

Zhang Han, Li Xiuli, Ma Chuanchuan, Wang Ke, Zhou Juan, Chen Jianhua, Wang Yonggang, Shi Yongyong

Abstract excerpt

BACKGROUND: ZDHHC2 is a member of the DHHC protein family, mediating palmitoylation of postsynaptic density-95 (PSD-95) and A-kinase-anchoring protein 79/150 (AKAP79/150). Genome-wide association studies (GWASs) have identified ZDHHC2 as a candidate gene for schizophrenia (SCZ). We aimed to fine-map variants of ZDHHC2 conferring risk to SCZ in the Han Chinese population. METHODS: Targeted sequencing of...

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PMID: 32180374
DOI: 10.1002/mgg3.1190
PMCID: PMC7336764

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