Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BDNF and COMT polymorphisms: relation to memory phenotypes in young adults with childhood-onset mood disorder.

Neuromolecular medicine - 1 Jan 2004

Strauss J, Barr C L, George C J, Ryan C M, King N, Shaikh S, Kovacs M, Kennedy J L

Abstract excerpt

Recent investigations in several species have suggested a role for brain-derived neurotrophic factor (BDNF) in memory, which may be mediated by the influence of BDNF on neuronal plasticity in the hippocampus. BDNF polymorphisms have also been associated with mood disorders. Catechol-O-methyltransferase (COMT) metabolizes dopamine and has been implicated in prefrontal function, another area of the brain relevant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Chemistry
Share to Brain-Derived Neurotrophic Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

Share to Dopamine

Share to Intelligence

Share to Memory

Share to Methionine

Share to Mood Disorders

Source

Identifiers

PMID: 15626819
DOI: 10.1385/NMM:5:3:181

Genes

BDNF
COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BDNF and COMT polymorphisms: relation to memory phenotypes in young adults with childhood-onset mood disorder.PMID 15626819Read ↗

Sex effects for the interaction of dopamine related genetic variants for COMT and BDNF on declarative memory performance.Semantic proximity Read ↗

The role of COMT gene variants in depression: Bridging neuropsychological, behavioral and clinical phenotypes.Semantic proximity Read ↗

BDNF and COMT polymorphisms have a limited association with episodic memory performance or engagement in complex cognitive activity in healthy older adults.Semantic proximity Read ↗

Effect of BDNF val(66)met polymorphism on declarative memory and its neural substrate: a meta-analysis.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT) genotypes are associated with varying soluble, but not membrane-bound COMT protein in the human prefrontal cortex.Semantic proximity Read ↗

Impact of brain-derived neurotrophic factor genetic polymorphism on cognition: A systematic review.Semantic proximity Read ↗

The impact of COMT polymorphisms on cognition in Bipolar Disorder: A review: Special Section on "Translational and Neuroscience Studies in Affective Disorders" Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovativ…Semantic proximity Read ↗

Genetic and vascular modifiers of age-sensitive cognitive skills: effects of COMT, BDNF, ApoE, and hypertension.Semantic proximity Read ↗

Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?Semantic proximity Read ↗

Effects of BDNF polymorphisms on brain function and behavior in health and disease.Semantic proximity Read ↗

Effect of Functional BDNF and COMT Polymorphisms on Symptoms and Regional Brain Volume in Frontotemporal Dementia and Corticobasal Syndrome.Semantic proximity Read ↗

Fine-mapping of the brain-derived neurotrophic factor (BDNF) gene supports an association of the Val66Met polymorphism with episodic memory.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.