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Diagnostic tool for the identification of <i>MLL</i> rearrangements including unknown partner genes

30 Dec 2004

Abstract excerpt

Approximately 50 different chromosomal translocations of the human MLL gene are currently known and associated with high-risk acute leukemia. The large number of different MLL translocation partner genes makes a precise diagnosis a demanding task. After their cytogenetic identification, only the most common MLL translocations are investigated by RT-PCR analyses, whereas infrequent or unknown MLL translocations...

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PMID: 15626757
DOI: 10.1073/pnas.0406994102

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