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11q23/MLL Acute Leukemia : Update of Clinical Aspects

1 Jan 2010

Abstract excerpt

Rearrangements of the MLL gene located at 11q23 are common chromosomal abnormalities associated with acute leukemia (AL), especially infant and secondary leukemia after previous treatment with DNA topoisomerase II inhibitors. 11q23/MLL abnormalities have been widely recognized as an important prognostic factor in AL. Over 70 chromosome partners of 11q23 have been identified to date, at least 50 of which have been...

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PMID: 21123966
DOI: 10.3960/jslrt.50.91

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