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The MLL recombinome of acute leukemias in 2017

13 Jul 2017

Abstract excerpt

Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained from 2345 acute leukemia patients. Genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and 11 novel TPGs were identified. Thus, a total of 135 different MLL rearrangements have been...

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Identifiers

PMID: 28701730
DOI: 10.1038/leu.2017.213

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