Article
Localization of bipolar susceptibility locus by molecular genetic analysis of the chromosome 12q23-q24 region in two pedigrees with bipolar disorder and Darier's disease.
The American journal of psychiatry - 1 Jan 2005
Green Elaine, Elvidge Gareth, Jacobsen Nick, Glaser Beate, Jones Ian, O'Donovan Michael C, Kirov George, Owen Michael J, Craddock Nick
Abstract excerpt
OBJECTIVE: The authors previously reported two families (pedigrees 324 and 5501) in which Darier's disease-a rare, autosomal dominant skin disease-and bipolar disorder cosegregate. In each of these families there is complete cosegregation of mood disorder with a segment of chromosome 12q23-q24, consistent with the existence of a highly penetrant dominant variant. Here molecular genetic analyses aimed at...
Topics
- Bipolar Disorder
- Chromosome Mapping
- Chromosomes, Human, Pair 12
- DNA Mutational Analysis
- Darier Disease
- Female
- Genetic Linkage
- Genetic Markers
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Male
- Models, Genetic