Article
Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1q.
Psychiatric genetics - 1 Jun 2003
Curtis David, Kalsi Gursharan, Brynjolfsson Jon, McInnis Melvin, O'Neill Jane, Smyth Ciaran, Moloney Eamonn, Murphy Patrice, McQuillin Andrew, Petursson Hannes, Gurling Hugh
Abstract excerpt
OBJECTIVE: To localize genes conferring susceptibility to bipolar affective disorder. METHODS: Seven families were selected on the basis of containing multiple cases of bipolar affective disorder present in three or more generations, an absence of schizophrenia and unilineal transmission. DNA samples from these families were genotyped with 365 microsatellite markers spaced at approximately 10 cM intervals across...
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