Article
Mutation rate of MAP2K4/MKK4 in breast carcinoma.
Human mutation - 1 Jan 2002
Su Gloria H, Song Jason J, Repasky Elizabeth A, Schutte Mieke, Kern Scott E
Abstract excerpt
The stress-activated protein kinase (SAPK) pathways represent phosphorylation cascades that convey pro-apoptotic signals. The relevant inputs include Ras proteins as well as exposure of cells to ultraviolet light, tumor-necrosis factor, and other stress-related inputs. The mitogen-activated protein kinase kinase (MAPKK) homolog MAP2K4 (MKK4, SEK, JNKK1) is a centrally-placed mediator of the SAPK pathways. MAP2K4...
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