Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Autoimmune Addison disease: pathophysiology and genetic complexity.

Nature reviews. Endocrinology - 31 Jan 2012

Mitchell Anna L, Pearce Simon H S

Abstract excerpt

Autoimmune Addison disease is a rare autoimmune disorder with symptoms that typically develop over months or years. Following the development of serum autoantibodies to the key steroidogenic enzyme, 21-hydroxylase, patients have a period of compensated or preclinical disease, characterized by elevations in adrenocortocotropic hormone and renin, before overt, symptomatic adrenal failure develops. We propose that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Addison Disease
Share to Adrenal Hormones and Disorders
Share to Autoimmune Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes and associated disorders

Share to Genetic Predisposition to Disease

Share to Hormonal Regulation and Hypertension

Source

Identifiers

PMID: 22290360
DOI: 10.1038/nrendo.2011.245

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autoimmune Addison disease: pathophysiology and genetic complexity.PMID 22290360Read ↗

The genetics of autoimmune Addison disease: past, present and future.Semantic proximity Read ↗

Understanding the genetics of autoimmune disease: two loci that regulate late onset Addison's disease in Portuguese Water Dogs.Semantic proximity Read ↗

GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibilitySemantic proximity Read ↗

A review of the genetics of hypoadrenocorticism.Semantic proximity Read ↗

Extended exome sequencing identifies BACH2 as a novel major risk locus for Addison's diseaseSemantic proximity Read ↗

Autoimmune Addison's Disease as Part of the Autoimmune Polyglandular Syndrome Type 1: Historical Overview and Current Evidence.Semantic proximity Read ↗

Genetic characterization of Addison's disease in Bearded Collies.Semantic proximity Read ↗

Cellular immunity and immunopathology in autoimmune Addison's disease.Semantic proximity Read ↗

Heritability of Addison's disease and prevalence of associated autoimmunity in a cohort of 112,100 Swedish twins.Semantic proximity Read ↗

Clinical implications of shared genetics and pathogenesis in autoimmune diseases.Semantic proximity Read ↗

A variant in RESF1 is associated with Addison's disease and multiple autoimmune syndrome in young Nova Scotia Duck Tolling Retrievers.Semantic proximity Read ↗

Autoimmune endocrine diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.