Article
CEBPalpha mutations in childhood acute myeloid leukemia.
Leukemia - 1 Mar 2005
Liang D-C, Shih L-Y, Huang C-F, Hung I-J, Yang C-P, Liu H-C, Jaing T-H, Wang L-Y, Chang W-H
Abstract excerpt
CEBPalpha: mutations have been described in adult acute myeloid leukemia (AML) and conferred a favorable prognosis. However, CEBPalpha mutation has not been reported in children. We investigated 117 children with de novo AML using DNA PCR assay followed by sequencing for each PCR product. CEBPalpha mutations were detected in seven patients, four had FAB M2, two M1 and one M4. CEBPalpha mutations only occurred in...
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