Article
Rapid and sensitive screening for CEBPA mutations in acute myeloid leukaemia.
British journal of haematology - 1 Oct 2008
Benthaus Tobias, Schneider Friederike, Mellert Gudrun, Zellmeier Evelyn, Schneider Stephanie, Kakadia Purvi M, Hiddemann Wolfgang, Bohlander Stefan K, Feuring-Buske Michaela, Braess Jan, Spiekermann Karsten, Dufour Annika
Abstract excerpt
The presence of CCAAT/enhancer binding protein alpha (CEBPA) gene mutations in patients with cytogenetically normal acute myeloid leukaemia (CN-AML) confers a favourable prognosis. Routine screening of all CN-AML patients for CEBPA mutations is therefore important for individual risk-adapted post-remission therapy and requires a fast and easy screening method. CEBPA mutations are distributed over the entire CEBPA...
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