Article
Molecular mechanisms underlying ketamine-mediated inhibition of sarcolemmal adenosine triphosphate-sensitive potassium channels.
Anesthesiology - 1 Jan 2005
Kawano Takashi, Oshita Shuzo, Takahashi Akira, Tsutsumi Yasuo, Tanaka Katsuya, Tomiyama Yoshinobu, Kitahata Hiroshi, Nakaya Yutaka
Abstract excerpt
BACKGROUND: Ketamine inhibits adenosine triphosphate-sensitive potassium (KATP) channels, which results in the blocking of ischemic preconditioning in the heart and inhibition of vasorelaxation induced by KATP channel openers. In the current study, the authors investigated the molecular mechanism...
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