Article
The -913 G/A glutamine:fructose-6-phosphate aminotransferase gene polymorphism is associated with measures of obesity and intramyocellular lipid content in nondiabetic subjects.
The Journal of clinical endocrinology and metabolism - 1 Mar 2005
Weigert Cora, Thamer Claus, Brodbeck Katrin, Guirguis Alke, Machicao Fausto, Machann Jürgen, Schick Fritz, Stumvoll Michael, Fritsche Andreas, Häring Hans U, Schleicher Erwin D
Abstract excerpt
Increases in glutamine:fructose-6-phosphate aminotransferase (GFAT) protein levels directly activate flux through the hexosamine biosynthetic pathway. This pathway has been involved as a fuel sensor in energy metabolism and development of insulin resistance. We screened the 5'-flanking region of the human GFAT gene for polymorphisms and subsequently genotyped 412 nondiabetic, metabolically characterized...
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