Article
Molecular screening of the human glutamine-fructose-6-phosphate amidotransferase 1 (GFPT1) gene and association studies with diabetes and diabetic nephropathy.
Molecular genetics and metabolism - 1 Aug 2004
Elbein Steven C, Zheng Hailing, Jia Yiwen, Chu Winston, Cooper Judith J, Hale Terri, Zhang Zhengxian
Abstract excerpt
Increased glucose metabolism through the hexosamine pathway may result in insulin resistance, impaired insulin secretion, and diabetic nephropathy. We hypothesized that variants of GFPT1 encoding glutamine-fructose-6-phosphate amidotransferase, the rate limiting enzyme in this pathway, could increase GFPT1 gene expression and thus susceptibility to diabetes and diabetic nephropathy. To test this hypothesis, we...
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