Article
Effects of a genetic variant rs13266634 in the zinc transporter 8 gene (SLC30A8) on insulin and lipid levels before and after a high-fat mixed macronutrient tolerance test in U.S. adults.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) - 1 May 2023
Yang Zhongyue, Wang Yining E, Kirschke Catherine P, Stephensen Charles B, Newman John W, Keim Nancy L, Cai Yimeng, Huang Liping
Abstract excerpt
BACKGROUND: The common C-allele of rs13266634 (c.973C>T or p.Arg325Trp) in SLC30A8 (ZNT8) is associated with increased risk of type 2 diabetes. While previous studies have examined the correlation of the variant with insulin and glucose metabolism, the effects of this variant on insulin and lipid responses after a lipid challenge in humans remain elusive. The goal of this study was to determine whether the...
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