Role of the PPARGC1A Gene and Its rs8192678 Polymorphism on Sport Performance, Aerobic Capacity, Muscle Adaptation and Metabolic Diseases: A Narrative Review.

doi:10.3390/genes15121631

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Role of the PPARGC1A Gene and Its rs8192678 Polymorphism on Sport Performance, Aerobic Capacity, Muscle Adaptation and Metabolic Diseases: A Narrative Review.

Genes - 20 Dec 2024

Varillas-Delgado David

Abstract excerpt

BACKGROUND/OBJECTIVES: The PPARGC1A gene, encoding the PGC-1α protein, is a critical regulator of energy metabolism, influencing mitochondrial biogenesis, fatty acid oxidation, and carbohydrate metabolism. This narrative review aims to evaluate the role of the PPARGC1A gene, with a specific focus on the c.1444G<A polymorphism (rs8192678), in sports performance, including its impact on aerobic capacity, muscle...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Athletic Performance

Share to Energy Metabolism

Share to PGC gene

Share to Metabolic Diseases

Share to Muscle, Skeletal

Share to Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 39766897
DOI: 10.3390/genes15121631
PMCID: PMC11675316

Genes

PPARGC1A
PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of the PPARGC1A Gene and Its rs8192678 Polymorphism on Sport Performance, Aerobic Capacity, Muscle Adaptation and Metabolic Diseases: A Narrative Review.PMID 39766897Read ↗

Meta-analyses of the association between the PPARGC1A Gly482Ser polymorphism and athletic performanceSemantic proximity Read ↗

The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review.Semantic proximity Read ↗

Association of Elite Sports Status with Gene Variants of Peroxisome Proliferator Activated Receptors and Their Transcriptional Coactivator.Semantic proximity Read ↗

The<i>PPARGC1A</i>gene Gly482Ser in Polish and Russian athletesSemantic proximity Read ↗

Linking Metabolic Disease With the PGC-1α Gly482Ser Polymorphism.Semantic proximity Read ↗

Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention.Semantic proximity Read ↗

The combined impact of metabolic gene polymorphisms on elite endurance athlete status and related phenotypes.Semantic proximity Read ↗

PPARGC1A gene polymorphism is associated with exercise-induced fat loss.Semantic proximity Read ↗

PPARGC1A genotype (Gly482Ser) predicts exceptional endurance capacity in European men.Semantic proximity Read ↗

Association between the PPARGC1A polymorphism and aerobic capacity in Japanese middle-aged men.Semantic proximity Read ↗

The PPARGC1A Gly482Ser polymorphism is associated with elite long-distance running performance.Semantic proximity Read ↗

Association of rs35767 polymorphism in the IGF1 gene with athletic performance in power and endurance sports: A meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.