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Structures of thymidine kinase 1 of human and mycoplasmic origin

20 Dec 2004

Abstract excerpt

Cytosolic thymidine kinase 1, TK1, is a well known cell-cycle-regulated enzyme of importance in nucleotide metabolism as well as an activator of antiviral and anticancer drugs such as 3'-azido-3'-deoxythymidine (AZT). We have now determined the structures of the TK1 family, the human and Ureaplasma urealyticum enzymes, in complex with the feedback inhibitor dTTP. The TK1s have a tetrameric structure in which each...

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PMID: 15611477
DOI: 10.1073/pnas.0406332102

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