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Article

Structure of a type II thymidine kinase with bound dTTP

30 Jan 2005

Abstract excerpt

The structure of human cytosolic thymidine kinase in complex with its feedback inhibitor 2'-deoxythymidine-5'-triphosphate was determined. This structure is the first representative of the type II thymidine kinases found in several pathogens. The structure deviates strongly from the known structures of type I thymidine kinases such as the Herpes simplex enzyme. It contains a zinc-binding domain with four...

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PMID: 15733844
DOI: 10.1016/j.febslet.2005.01.034

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