Article

EXD2 and WRN exonucleases are required for interstrand crosslink repair in <i>Drosophila</i>

2018-03-18

Abstract excerpt

Interstrand crosslinks (ICLs) present a major threat to genome integrity, preventing both the correct transcription of active chromatin and complete replication of the genome. This is exploited in genotoxic chemotherapy where ICL induction is used to kill highly proliferative cancer cells. Repair of ICLs involves a complex interplay of numerous proteins, including those in the Fanconi anemia (FA) pathway, though a...

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Literature Corpus work: 0df59c3d-d863-57e5-8682-6b0d70809fc8
DOI: 10.1101/284307

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