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Article

Egghead and brainiac are essential for glycosphingolipid biosynthesis in vivo.

The Journal of biological chemistry - 11 Feb 2005

Wandall Hans H, Pizette Sandrine, Pedersen Johannes W, Eichert Heather, Levery Steven B, Mandel Ulla, Cohen Stephen M, Clausen Henrik

Abstract excerpt

The Drosophila genes, brainiac and egghead, encode glycosyltransferases predicted to act sequentially in early steps of glycosphingolipid biosynthesis, and both genes are required for development in Drosophila. egghead encodes a beta4-mannosyltransferase, and brainiac encodes a beta3-N-acetylglucosaminyltransferase predicted by in vitro analysis to control synthesis of the glycosphingolipid core structure,...

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PMID: 15611100
DOI: 10.1074/jbc.C400571200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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