Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Drosophila neurally altered carbohydrate mutant has a defective Golgi GDP-fucose transporter.

The Journal of biological chemistry - 24 Aug 2012

Geisler Christoph, Kotu Varshika, Sharrow Mary, Rendić Dubravko, Pöltl Gerald, Tiemeyer Michael, Wilson Iain B H, Jarvis Donald L

Abstract excerpt

Studying genetic disorders in model organisms can provide insights into heritable human diseases. The Drosophila neurally altered carbohydrate (nac) mutant is deficient for neural expression of the HRP epitope, which consists of N-glycans with core α1,3-linked fucose residues. Here, we show that a conserved serine residue in the Golgi GDP-fucose transporter (GFR) is substituted by leucine in nac(1) flies, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila melanogaster
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epitopes

Share to Glycosylation

Share to Golgi Apparatus

Share to Monosaccharide Transport Proteins

Share to Nerve Tissue Proteins

Share to Protein Transport

Source

Open in PubMed Open full text

Identifiers

PMID: 22745127
DOI: 10.1074/jbc.M112.379313
PMCID: PMC3436151

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Drosophila neurally altered carbohydrate mutant has a defective Golgi GDP-fucose transporter.PMID 22745127Read ↗

Notch deficiency implicated in the pathogenesis of congenital disorder of glycosylation IIc.Semantic proximity Read ↗

Functional analysis of glycosylation using Drosophila melanogaster.Semantic proximity Read ↗

The N's and O's of Drosophila glycoprotein glycobiology.Semantic proximity Read ↗

Requirement for a core 1 galactosyltransferase in the Drosophila nervous system.Semantic proximity Read ↗

Synaptic roles for phosphomannomutase type 2 in a new Drosophila congenital disorder of glycosylation disease modelSemantic proximity Read ↗

COG7 deficiency in Drosophila generates multifaceted developmental, behavioral and protein glycosylation phenotypes.Semantic proximity Read ↗

Overelaborated synaptic architecture and reduced synaptomatrix glycosylation in a Drosophila classic galactosemia disease model.Semantic proximity Read ↗

Neuromuscular Defects in a Drosophila Model of the Congenital Disorder of Glycosylation SLC35A2-CDG.Semantic proximity Read ↗

Drosophila models of phosphatidylinositol glycan biosynthesis class A congenital disorder of glycosylation (PIGA-CDG) mirror patient phenotypes.Semantic proximity Read ↗

Two pathways for importing GDP-fucose into the endoplasmic reticulum lumen function redundantly in the O-fucosylation of Notch in Drosophila.Semantic proximity Read ↗

Glucuronylated core 1 glycans are required for precise localization of neuromuscular junctions and normal formation of basement membranes on Drosophila muscles.Semantic proximity Read ↗

A genome-wide CRISPR screen identifies the glycosylation enzyme DPM1 as a modifier of DPAGT1 deficiency and ER stressSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.