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Article

Role of B13 Glu in insulin assembly. The hexamer structure of recombinant mutant (B13 Glu-->Gln) insulin.

Journal of molecular biology - 20 Dec 1992

Bentley G A, Brange J, Derewenda Z, Dodson E J, Dodson G G, Markussen J, Wilkinson A J, Wollmer A, Xiao B

Abstract excerpt

The assembly of the insulin hexamer brings the six B13 glutamate side-chains at the centre into close proximity. Their mutual repulsion is unfavourable and zinc co-ordination to B10 histidine is necessary to stabilize the well known zinc-containing hexamers. Since B13 is always a carboxylic acid in all known sequences of hexamer forming insulins, it is likely to be important in the hormone's biology. The mutation...

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Identifiers

PMID: 1361949
DOI: 10.1016/0022-2836(92)90323-c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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