Article
beta-Catenin gene mutation in human hair follicle-related tumors.
Pathology international - 1 Jul 2001
Kajino Y, Yamaguchi A, Hashimoto N, Matsuura A, Sato N, Kikuchi K
Abstract excerpt
beta-Catenin, a multifunctional protein related to the adherens junction and to signal transduction, is a key molecule of cell proliferation, and it is central to epithelial architecture, regulating the polarity of cells and tissues. beta-Catenin stabilization may play a key role in epidermal signaling leading to hair development, and its aberrant activation may be implicated in formation of hair tumors. Several...
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