Article
The Wnt/β-catenin pathway is deregulated in cemento-ossifying fibromas.
Oral surgery, oral medicine, oral pathology and oral radiology - 1 Feb 2018
Pereira Thaís Dos Santos Fontes, Diniz Marina Gonçalves, França Josiane Alves, Moreira Rennan Garcias, Menezes Grazielle Helena Ferreira de, Sousa Sílvia Ferreira de, Castro Wagner Henriques de, Gomes Carolina Cavaliéri, Gomez Ricardo Santiago
Abstract excerpt
OBJECTIVE: The molecular pathogenesis of cemento ossifying fibroma (COF) is unclear. The purpose of this study was to investigate mutations in 50 oncogenes and tumor suppressor genes, including APC and CTNNB1, in which mutations in COF have been previously reported. In addition, we assessed the transcriptional levels of the Wnt/β-catenin pathway genes in COF. STUDY DESIGN: We used a quantitative polymerase chain...
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