Article
Recurrent CTNNB1 mutations in craniofacial osteomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2022
Baumhoer Daniel, Berthold Ruth, Isfort Ilka, Heinst Lorena, Ameline Baptiste, Grünewald Inga, Thieringer Florian M, Rudack Claudia, Wardelmann Eva, Vieth Volker, Sperveslage Jan, Trautmann Marcel, Hartmann Wolfgang
Abstract excerpt
Osteoma is a benign bone forming tumor predominantly arising on the surface of craniofacial bones. While the vast majority of osteomas develops sporadically, a small subset of cases is associated with Gardner syndrome, a phenotypic variant of familial adenomatous polyposis caused by mutations in the APC gene resulting in aberrant activation of WNT/β-catenin signaling. In a sequencing analysis on a cohort of...
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