Article
Interaction between the uncoupling protein 2 -866G>A gene variant and cigarette smoking to increase oxidative stress in subjects with diabetes.
Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Jan 2008
Stephens Jeffrey W, Dhamrait Sukhbir S, Mani Ali R, Acharya Jayshree, Moore Kevin, Hurel Steven J, Humphries Steve E
Abstract excerpt
BACKGROUND AND AIMS: Increased oxidative stress is associated with coronary heart disease (CHD). The mitochondrial uncoupling protein-2 (UCP2) negatively regulates reactive oxygen species generation. We have observed that a common variant (-866G>A) in the promoter region of UCP2 is associated with increased CHD risk in healthy men and increased oxidative stress in diabetic men with CHD. The aim of the current...
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