Article
Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity.
Molecular and cellular biology - 1 Jan 2005
Osswald Christina, Baumgarten Katharina, Stümpel Frank, Gorboulev Valentin, Akimjanova Marina, Knobeloch Klaus-Peter, Horak Ivan, Kluge Reinhart, Joost Hans-Georg, Koepsell Hermann
Abstract excerpt
The product of the intronless single copy gene RSC1A1, named RS1, is an intracellular 617-amino-acid protein that is involved in the regulation of the Na(+)-d-glucose cotransporter SGLT1. We generated and characterized RS1 knockout (RS1(-/-) mice. In the small intestines of RS1(-/-) mice, the SGLT1 protein was up-regulated sevenfold compared to that of wild-type mice but was not changed in the kidneys. The...
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