Article
Defects in Na+/glucose cotransporter (SGLT1) trafficking and function cause glucose-galactose malabsorption.
Nature genetics - 1 Feb 1996
Martín M G, Turk E, Lostao M P, Kerner C, Wright E M
Abstract excerpt
Cotransporters harness ion gradients to drive 'active' transport of substrates into cells, for example, the Na+/glucose cotransporter (SGLT1) couples sugar transport to Na+ gradients across the intestinal brush border. Glucose-Galactose Malabsorption (GGM) is caused by a defect in SGLT1. The phen...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Transport
- Cell Membrane
- Galactose
- Genetic Carrier Screening
- Glucose
- Homozygote
- Humans
- Malabsorption Syndromes
- Membrane Glycoproteins
- Membrane Potentials
- Methylglucosides
- Molecular Sequence Data
- Monosaccharide Transport Proteins
- Mutation
- Oocytes