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Article

A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells.

The Journal of clinical investigation - 1 Dec 2004

Miura Masako, Chen Xiao-Dong, Allen Matthew R, Bi Yanming, Gronthos Stan, Seo Byoung-Moo, Lakhani Saquib, Flavell Richard A, Feng Xin-Hua, Robey Pamela Gehron, Young Marian, Shi Songtao

Abstract excerpt

Caspase-3 is a critical enzyme for apoptosis and cell survival. Here we report delayed ossification and decreased bone mineral density in caspase-3-deficient (Casp3(-/-) and Casp3(+/-)) mice due to an attenuated osteogenic differentiation of bone marrow stromal stem cells (BMSSCs). The mechanism involved in the impaired differentiation of BMSSCs is due, at least partially, to the overactivated TGF-beta/Smad2...

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Identifiers

PMID: 15599395
DOI: 10.1172/JCI20427
PMCID: PMC535063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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