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Smad 3 May Regulate Follicular Growth in the Mouse Ovary1

1 Apr 2002

Abstract excerpt

Although Smad 3 is known to serve as a signaling intermediate for the transforming growth factor beta (TGFbeta) family in nonreproductive tissues, its role in the ovary is unknown. Thus, we used a recently generated Smad 3-deficient (Smad 3-/-) mouse model to test the hypothesis that Smad 3 alters female fertility and regulates the growth of ovarian follicles from the primordial stage to the antral stage. In...

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PMID: 11906909
DOI: 10.1095/biolreprod66.4.917

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