Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of caspases is required for osteoblastic differentiation.

The Journal of biological chemistry - 28 Nov 2003

Mogi Makio, Togari Akifumi

Abstract excerpt

Previous studies have shown that mouse osteoblastic MC3T3-E1 cells undergo apoptosis when exposed to a mixture of proinflammatory cytokines. Bone morphogenetic protein (BMP)s are important regulators of osteoblast differentiation. Because regulation of osteoblastic differentiation is poorly understood, we sought to determine if BMP-4-induced differentiation of osteoblastic cells depends on the activity of the key...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alkaline Phosphatase
Share to Bone Morphogenetic Protein 4
Share to Bone Morphogenetic Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caspase 3

Share to Caspase 8

Share to Caspase 9

Share to Caspases

Share to Parathyroid Hormone

Source

Identifiers

PMID: 12954609
DOI: 10.1074/jbc.M307055200

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of caspases is required for osteoblastic differentiation.PMID 12954609Read ↗

A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells.Semantic proximity Read ↗

Apoptosis during bone-like tissue development in vitro.Semantic proximity Read ↗

Role of Smad3, acting independently of transforming growth factor-beta, in the early induction of Wnt-beta-catenin signaling by parathyroid hormone in mouse osteoblastic cells.Semantic proximity Read ↗

Perspective: Quantifying Osteoblast and Osteocyte Apoptosis: Challenges and RewardsSemantic proximity Read ↗

Inorganic phosphate induces apoptosis of osteoblast-like cells in culture.Semantic proximity Read ↗

Loss of the differentiated phenotype precedes apoptosis of ROS 17/2.8 osteoblast-like cells.Semantic proximity Read ↗

Proliferation, differentiation and apoptosis in connexin43-null osteoblasts.Semantic proximity Read ↗

Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells.Semantic proximity Read ↗

Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: An in vitro model of osteoblast developmentSemantic proximity Read ↗

Active role of chondrocyte apoptosis in endochondral ossificationSemantic proximity Read ↗

Bone Morphogenetic Proteins, Extracellular Matrix, and Mitogen-Activated Protein Kinase Signaling Pathways Are Required for Osteoblast-Specific Gene Expression and Differentiation in MC3T3-E1 CellsSemantic proximity Read ↗

Role of caspases in cleavage of lamin A/C and PARP during apoptosis in macrophages infected with a periodontopathic bacteriumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.