Article
Microarray genotyping resource to determine population stratification in genetic association studies of complex disease.
BioTechniques - 1 Dec 2004
Tebbutt Scott J, He Jian-Qing, Burkett Kelly M, Ruan Jian, Opushnyev Igor V, Tripp Ben W, Zeznik Jeffrey A, Abara Chiaka O, Nelson Colleen C, Walley Keith R
Abstract excerpt
We have developed a robust microarray genotyping chip that will help advance studies in genetic epidemiology. In population-based genetic association studies of complex disease, there could be hidden genetic substructure in the study populations, resulting in false-positive associations. Such population stratification may confound efforts to identify true associations between genotype/haplotype and phenotype....
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