Article
Association of ALDH1 promoter polymorphisms with alcohol-related phenotypes in southwest California Indians.
Alcoholism, clinical and experimental research - 1 Oct 2004
Ehlers Cindy L, Spence John P, Wall Tamara L, Gilder David A, Carr Lucinda G
Abstract excerpt
BACKGROUND: Cytosolic aldehyde dehydrogenase (ALDH1A1) is an important enzyme in the metabolism of acetaldehyde and the synthesis of retinoic acid. Two polymorphisms in the promoter region of ALDH1A1-ALDH1A1*2 and ALDH1A1*3-have recently been identified and described in small samples of Asian, Caucasian, and African individuals. The aim of this study was to determine the prevalence of these polymorphisms in a...
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