Article
Distinct but overlapping T helper epitopes in the 37-58 region of SSX-2.
Clinical immunology (Orlando, Fla.) - 1 Jan 2005
Ayyoub Maha, Merlo Andrea, Hesdorffer Charles S, Speiser Daniel, Rimoldi Donata, Cerottini Jean-Charles, Ritter Gerd, Chen Yao-Tseng, Old Lloyd J, Stevanovic Stefan, Valmori Danila
Abstract excerpt
Because of their specific expression in tumors of different histological types, the products of the SSX genes are important candidate targets for development of cancer vaccines. We have previously identified two immunodominant SSX-2-derived T cell epitopes recognized by HLA-A2-restricted CD8+ T cells (SSX-2 41-49) and HLA-DR11-restricted CD4+ T cells (SSX-2 45-59), respectively. In this study, we report the...
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