Article
Identification of an SSX-2 epitope presented by dendritic cells to circulating autologous CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2004
Ayyoub Maha, Hesdorffer Charles S, Metthez Genevieve, Stevanovic Stefan, Ritter Gerd, Chen Yao-Tseng, Old Lloyd J, Speiser Daniel, Cerottini Jean-Charles, Valmori Danila
Abstract excerpt
Accumulating evidence supports the requirement for both tumor-specific CD8(+) and CD4(+) T cell responses for efficient tumor rejection to occur. Because of its expression in different tumor types, the cancer/testis Ag encoded by the synovial sarcoma X breakpoint 2 (SSX-2) gene is among the most relevant candidates for the development of generic cancer vaccines. The immunogenicity of SSX-2 has been previously...
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