Article
Identification of NY-ESO-1 epitopes presented by human histocompatibility antigen (HLA)-DRB4*0101-0103 and recognized by CD4(+) T lymphocytes of patients with NY-ESO-1-expressing melanoma.
The Journal of experimental medicine - 21 Feb 2000
Jäger E, Jäger D, Karbach J, Chen Y T, Ritter G, Nagata Y, Gnjatic S, Stockert E, Arand M, Old L J, Knuth A
Abstract excerpt
NY-ESO-1 is a member of the cancer-testis family of tumor antigens that elicits strong humoral and cellular immune responses in patients with NY-ESO-1-expressing cancers. Since CD4(+) T lymphocytes play a critical role in generating antigen-specific cytotoxic T lymphocyte and antibody responses, we searched for NY-ESO-1 epitopes presented by histocompatibility leukocyte antigen (HLA) class II molecules....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.