Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein.

The Journal of clinical investigation - 1 May 1990

Kohsaka H, Yamamoto K, Fujii H, Miura H, Miyasaka N, Nishioka K, Miyamoto T

Abstract excerpt

To analyze the autoepitopes on the SS-B/La protein, a cDNA covering the entire region coding the protein was isolated from a human cDNA library. The cDNA was subcloned into an expression plasmid vector, pEX, to express its protein product as a fusion protein with cro-beta-galactosidase in Escherichia coli. A recombinant pEX plasmid expressing three-fourths of the protein (amino acid 112-408) was also constructed....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cloning, Molecular

Share to Molecular Sequence Data

Share to Mutation

Share to Plasmids

Share to Sequence Homology, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 1692037
DOI: 10.1172/JCI114606
PMCID: PMC296607

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein.PMID 1692037Read ↗

T Cell Mediated Conversion of a Non-Anti-La Reactive B Cell to an Autoreactive Anti-La B Cell by Somatic HypermutationSemantic proximity Read ↗

Analysis of expression of an alternative La (SS-B) cDNA and localization of the encoded N- and C-terminal peptides.Semantic proximity Read ↗

Detection of Antibodies to a Recombinant gag Protein Derived from Human Endogenous Retrovirus Clone 4-1 in Autoimmune DiseasesSemantic proximity Read ↗

Distinct but overlapping T helper epitopes in the 37-58 region of SSX-2.Semantic proximity Read ↗

The nuclear autoantigen La/SS-B: mapping and sequencing of the gene and the three retropseudogenes.Semantic proximity Read ↗

Intra- and intermolecular spreading of autoimmunity involving the nuclear self-antigens La (SS-B) and Ro (SS-A).Semantic proximity Read ↗

Clinical, immunological, and immunogenetic aspects of autoantibody production against Ro/SSA, La/SSB and their linear epitopes in primary Sjögren's syndrome (pSS): a European multicentre study.Semantic proximity Read ↗

Isolation of rat cDNA clones coding for the autoantigen SS-B/La: detection of species-specific variations.Semantic proximity Read ↗

Alkali hydrolysis of recombinant proteins allows for the rapid identification of class I MHC-restricted CTL epitopes.Semantic proximity Read ↗

B cell epitope on the U1 snRNP-C autoantigen contains a sequence similar to that of the herpes simplex virus protein.Semantic proximity Read ↗

Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen.Semantic proximity Read ↗

52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.