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Mutation of Putative N-Glycosylation Sites on Dengue Virus NS4B Decreases RNA Replication

16 Apr 2015

Abstract excerpt

UNLABELLED: Dengue virus (DENV) nonstructural protein 4B (NS4B) is an endoplasmic reticulum (ER) membrane-associated protein, and mutagenesis studies have revealed its significance in viral genome replication. In this work, we demonstrated that NS4B is an N-glycosylated protein in virus-infected cells as well as in recombinant protein expression. NS4B is N glycosylated at residues 58 and 62 and exists in two...

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PMID: 25878113
DOI: 10.1128/jvi.00423-15

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