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Article

Growth restriction of dengue virus type 2 by site-specific mutagenesis of virus-encoded glycoproteins.

1 Nov 1998

Abstract excerpt

The three flavivirus glycoproteins prM, E and NS1 are formed by post-translational cleavage and are glycosylated by the addition of N-linked glycans. NS1 may form homodimers, whereas E may form homodimers, homotrimers or heterodimers (prM-E). Modification of these processes by mutagenesis of the proteins has the potential to generate viruses that are restricted in growth and are possible vaccine candidates. Using...

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PMID: 9820138
DOI: 10.1099/0022-1317-79-11-2631

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